Well I suppose it has to happen at some point. The end of the world as we know it. No not the end of the world because in most cases Earth will continue to be here long after we're gone. It bothers me when people say the end of the world because short of our planet being totally vaporized into space dust, it's going to keep spinning around the Sun whether it can support life or not. There is the the chance in about 12 billion years that humans are still on the planet when the Sun finally runs out of hydrogen to fuse and then goes through helium fusion and becomes a Red Giant, where it expands out to the orbit of Mars. Even then it would take awhile before Earth felt some lasting effects. Long story short it would take so many billions of years for that to happen that man as we know it will have become something quite different than what we are now.
Anyway pick your ending. Zombie invasion, hit by an asteroid (or meteor), global climate meltdown, or good old fashion nuclear winter. According to most science fiction there are really two ways things can go in the future. Either there will be an apocalypse and the world will be turned into burnt out shell where people fight to survive and it's questioned if mankind will burn out as well. The other option is that civilization turns into some kind of utopia. The caveat with option two is that often times you have to go through option one to get to the society of bliss.
In most of the disaster movies there are only about twenty minutes worth of signs that something is wrong. And the only ones to notice it are the quirky scientist guys that are amazingly smart, but somehow aren't reputable enough for anyone to take their work seriously until the core of the Earth has stopped spinning or The White House is covered in an ice storm that won't end for two years. The more likely scenario is that the events that are leading to the end of the world (as we know it) have already been set in motion. It's not going to be everything fine one day and the next we're in a panic because the sky is raining fire. Even when the dead rise from their graves there's always going to be a couple days of reports that corpses are running amok. So try to watch the news at least once a week to get a heads up on those sort of things.
The part that interests me is how people will react in the face of such an event. Some will be in denial that anything could be happening. The scope of the event will be just too large for their brains to handle. And it's hard to blame them because of the constant barrage of things we're told we should be afraid of. While I don't believe H1N1 is going to be a pandemic that will wipe out humanity, I do wonder if people think H3N3 could be. Beware of Captain Trips. Then you have the other group of people. These are the ones who see what's happening and just deal with it. Maybe they stock up on canned food and shotguns (which is probably a good idea anyway). Maybe they're just quick enough to avoid the initial wave of undead and get setup on a nice fortified island of safety. These people will do whatever is necessary to survive.
The really depressing part about surviving the apocalypse is that's all you're doing. You're just surviving. In most of the stories about the end of the world the people in it are just trying to make it to tomorrow. There aren't a lot of spare moments spent on hopes and dreams. Maybe that's how things were a few thousand years ago. Less time was spent on worrying about your feelings or if your company will sell another dozen widgets and more time was spent on finding a clean water source or where your next meal will come from. I'm not saying that things were better back then, but it was a much simpler definition of wants versus needs.
Maybe all the survivors are doing is surviving because they know how far things have been set backwards. If you think about it, this is the most advanced our society has ever been, to our knowledge anyway. That means we have so much farther to fall should some catastrophic event happen. If something were to kill all electronic devices in 1879 the biggest hit would be the first commercial power station in San Francisco. At least as far as regular people could tell. For the most part it wouldn't be a lasting setback to the future of man. You kill power today and the effects are instantaneous. Our reliance on electronics makes us even more susceptible to drastic reversals in progress as a society. Imagine what life would be like if an EMP hit most of America. Even if we were capable of replacing the electronics that were destroyed, the time that we're down could lead to chaos. If it happened in the summer you'd lose people in the south. If it happened in the winter you'd lose people in the north. A week without lights, or phones, or the blessed Internet and society as we know it could start to crumble around the edges. The longer we spend in the dark, the more feral we become.
And that's just an electromagnetic pulse. Imagine if at the start of the industrial revolution there was a cataclysmic event that set everything back 200 years. Would things progress the same way that they were going in the first place? I know life finds a way to survive, but how does it find its way to progress beyond just survival? What happens to a society that is forced to go backwards and start over? Do we learn from the mistakes we made? Maybe there will be those who look at technology as the root of the problem and prefer we go back to a more nomadic existence. Maybe we rebuild and in time we get back to where we are now. New York City is built on the remains of the old city. So it is possible.
There are so many things that could finish us off that if you thought about it for too long you might go a little crazy. People like to think we have the means to change the world, but really we just have the means to change things enough that we can't live on the planet anymore. So we can create our own apocalypse either with weapons of mass destruction or through the inadvertent creation of some super virus. Personally I think the Large Hadron Collider has some potential to warp all matter as we know it. The Earth itself could have some global problem be it climate changes or killer trees. And if that's not enough you have other outside forces (think meteor, not aliens). I guess it just comes down to enjoying what you have while you have it because we could be already on our way to the end of things and just not know it yet.